Rankings
| # | Player | Team | G | Att | Yds▼ | YPC | TD | EPA |
|---|---|---|---|---|---|---|---|---|
| 1 | James CookRB | BUF | 19 | 348 | 1,784 | 5.1 | 12 | -0.8 |
| 2 | Derrick HenryRB | BAL | 17 | 307 | 1,595 | 5.2 | 16 | 9.2 |
| 3 | Jonathan TaylorRB | IND | 17 | 323 | 1,585 | 4.9 | 18 | 18.8 |
| 4 | Bijan RobinsonRB | ATL | 17 | 287 | 1,478 | 5.1 | 7 | -12.3 |
| 5 | Kyren WilliamsRB | LA | 20 | 303 | 1,435 | 4.7 | 12 | 8.0 |
| 6 | De'Von AchaneRB | MIA | 16 | 238 | 1,350 | 5.7 | 8 | 14.0 |
| 7 | Kenneth Walker IIIRB | SEA | 20 | 286 | 1,340 | 4.7 | 9 | -10.0 |
| 8 | Christian McCaffreyRB | SF | 19 | 337 | 1,285 | 3.8 | 10 | -26.0 |
| 9 | Saquon BarkleyRB | PHI | 17 | 306 | 1,246 | 4.1 | 7 | -27.4 |
| 10 | Jahmyr GibbsRB | DET | 17 | 243 | 1,223 | 5.0 | 13 | -2.7 |
| 11 | D'Andre SwiftRB | CHI | 18 | 255 | 1,217 | 4.8 | 10 | 12.5 |
| 12 | Javonte WilliamsRB | DAL | 16 | 252 | 1,201 | 4.8 | 11 | 12.2 |
| 13 | Travis EtienneRB | JAX | 18 | 270 | 1,174 | 4.3 | 7 | -16.3 |
| 14 | Rico DowdleRB | CAR | 18 | 241 | 1,085 | 4.5 | 6 | -4.0 |
| 15 | Tony PollardRB | TEN | 17 | 242 | 1,082 | 4.5 | 5 | -21.7 |
| 16 | Breece HallRB | NYJ | 16 | 243 | 1,065 | 4.4 | 4 | -22.3 |
| 17 | Chase BrownRB | CIN | 17 | 232 | 1,019 | 4.4 | 6 | -4.2 |
| 18 | Jaylen WarrenRB | PIT | 17 | 223 | 1,001 | 4.5 | 6 | -4.2 |
| 19 | TreVeyon HendersonRB | NE | 21 | 210 | 987 | 4.7 | 9 | -2.8 |
| 20 | Josh JacobsRB | GB | 16 | 253 | 984 | 3.9 | 13 | -19.6 |
| 21 | Ashton JeantyRB | LV | 17 | 266 | 975 | 3.7 | 5 | -65.2 |
| 22 | Blake CorumRB | LA | 20 | 171 | 865 | 5.1 | 6 | 14.3 |
| 23 | Kyle MonangaiRB | CHI | 19 | 190 | 846 | 4.5 | 5 | -4.1 |
| 24 | Woody MarksRB | HOU | 18 | 229 | 832 | 3.6 | 3 | -35.5 |
| 25 | Quinshon JudkinsRB | CLE | 14 | 230 | 827 | 3.6 | 7 | -25.1 |
| 26 | Rhamondre StevensonRB | NE | 18 | 188 | 820 | 4.4 | 7 | -25.8 |
| 27 | Jacory Croskey-MerrittRB | WAS | 17 | 175 | 805 | 4.6 | 8 | -6.5 |
| 28 | J.K. DobbinsRB | DEN | 10 | 153 | 772 | 5.0 | 4 | 4.2 |
| 29 | Jordan MasonRB | MIN | 16 | 159 | 758 | 4.8 | 6 | -5.8 |
| 30 | Zach CharbonnetRB | SEA | 17 | 189 | 750 | 4.0 | 12 | -1.2 |
| 31 | Tyrone Tracy Jr.RB | NYG | 15 | 176 | 740 | 4.2 | 2 | -9.8 |
| 32 | David MontgomeryRB | DET | 17 | 158 | 716 | 4.5 | 8 | -0.6 |
| 33 | Josh AllenQB | BUF | 18 | 135 | 678 | 5.0 | 16 | 49.9 |
| 34 | Kimani VidalRB | LAC | 14 | 166 | 674 | 4.1 | 3 | -16.8 |
| 35 | Drake MayeQB | NE | 21 | 132 | 628 | 4.8 | 5 | 20.4 |
| 36 | Kareem HuntRB | KC | 17 | 163 | 611 | 3.7 | 8 | 9.7 |
| 37 | RJ HarveyRB | DEN | 19 | 165 | 597 | 3.6 | 7 | -26.6 |
| 38 | Bucky IrvingRB | TB | 10 | 173 | 588 | 3.4 | 1 | -35.6 |
| 39 | Rachaad WhiteRB | TB | 17 | 132 | 572 | 4.3 | 4 | 10.4 |
| 40 | Nick ChubbRB | HOU | 17 | 136 | 568 | 4.2 | 3 | -8.6 |
| 41 | Kenneth GainwellRB | PIT | 18 | 120 | 557 | 4.6 | 5 | -2.1 |
| 42 | Chuba HubbardRB | CAR | 16 | 147 | 557 | 3.8 | 3 | -15.0 |
| 43 | Justin HerbertQB | LAC | 17 | 93 | 555 | 6.0 | 2 | 17.5 |
| 44 | Aaron JonesRB | MIN | 12 | 132 | 548 | 4.2 | 2 | -2.4 |
| 45 | Omarion HamptonRB | LAC | 10 | 125 | 544 | 4.4 | 4 | -1.5 |
| 46 | Tyler AllgeierRB | ATL | 17 | 143 | 514 | 3.6 | 8 | -11.6 |
| 47 | Chris Rodriguez Jr.RB | WAS | 12 | 112 | 500 | 4.5 | 6 | 6.2 |
| 48 | Emanuel WilsonRB | GB | 18 | 126 | 499 | 4.0 | 3 | -7.9 |
| 49 | Jaxson DartQB | NYG | 14 | 86 | 487 | 5.7 | 9 | 38.1 |
| 50 | Alvin KamaraRB | NO | 11 | 131 | 471 | 3.6 | 1 | -28.8 |